Thiolase-like, subgroup <p>This entry represents a subgroup of thiolase-like domains (missing a few subfamilies). These domains have a 3-layer structure with an alpha/beta/alpha topology. This domain usually occurs in two similar copies that are related by a pseudo-dyad, and which arose through duplication. The proteins in this entry can be split into two groups: those related to thiolase, and those related to chalcone synthase. The thiolase-like enzymes include:</p><p> <ul><li>Thiolase, where the topology of each domain is similar to the first domain of phosphoglucomutase [<cite idref="PUB00020434"/>]</li><li>Beta-ketoacyl-ACP synthases types I (<db_xref db="EC" dbkey="2.3.1.41"/>) and II (<db_xref db="EC" dbkey="2.3.1.179"/>) [<cite idref="PUB00036842"/>, <cite idref="PUB00019762"/>]</li><li>Actinorhodin polyketide beta-ketoacyl synthases 1 and 2 [<cite idref="PUB00031547"/>]</li></ul> </p><p>The chalcone synthase-like enzymes include:</p><p> <ul><li>Chalcone synthase (<db_xref db="EC" dbkey="2.3.1.74"/>) [<cite idref="PUB00014381"/>]</li><li>Polyketide synthases [<cite idref="PUB00031426"/>]</li><li>Dihydropinosylvin synthase [<cite idref="PUB00031633"/>]</li></ul> </p>